Support Alert

Drug safety update: Clozapine: reminder of potentially fatal risk of intestinal obstruction, faecal impaction, and paralytic ileus

The Medicines and Healthcare products Regulatory Agency (MHRA) has issued a drug safety update for Clozapine. If constipation occurs during treatment with clozapine (Clozaril, Denzapine, Zaponex), it is vital that it is recognised and actively treated.

Further details of the safety update, advice and recommendations are available on the MHRA website.